Sinus node inhibitors

What they do

Sinus node inhibitor, ivabradine, reduces heart rate by a novel mechanism and reduces the frequency of impulses from the sinus node, which is the place in the right atrium of the heart that controls the heart rate. This agent is well-tolerated and effective.

Clinical research has shown that ivabradine when administered to patients with symptomatic chronic heart failure, who are on optimal standard medical therapy including betablockers, reduces heart rate and significantly reduces cardiovascular mortality or the number of heart failure admissions to hospital. This drug is recommended for patients who have a persistent heart rate ≥ 70 beats/min* in addition to a maximally tolerated betablocker dose (*in Europe the European Medecine Agency says ≥ 75).

Side effects

Ivabradine is extremely tolerated with very few side effects. Patients may frequently notice minor visual disturbances that appear as transitory bright lights (luminous phenomena). Patients should be informed of this frequent side effect which is not serious and rarely requires discontinuation of the drug. The agent may also occasionally slow heart rate substantially which would require a reduction of the dose or discontinuation of the drug.

Also know as:

  • Ivabradine
    (Procolaran®, Coraxan®, Coralan®, Corlentor®)

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ESC Guidelines for Heart Failure

What patients need to know

This guide for patients from the European Society of Cardiology aims to provide an overview of the latest evidence-based recommendations for the diagnosis and treatment of heart failure.

In particular, it should help patients to understand the:

  • main types of heart failure
  • medicines used to treat heart failure
  • devices that may be appropriate
  • importance of rehabilitation
  • management by a multidisciplinary team
  • importance of self-care in managing your own condition

Learn more


A series of 9 simple, captivating animations explaining heart failure and its treatment.

These narrated animations explain how a healthy heart works, what happens to it in heart failure and how various treatments work to improve your health.


In this section you can watch, listen or read interviews with other people with heart failure and their caregivers.


and share your own views and experiences with other patients, families and caregivers. is a European Society of Cardiology website

The website was developed under the direction of the Heart Failure Association of the European Society of Cardiology (ESC). The ESC is a world leader in the discovery and dissemination of best practices in cardiovascular medicine. Our members and decision-makers are healthcare professionals who volunteer their time and expertise to represent professionals in the field of cardiology in Europe and beyond.

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