{"id":8136,"date":"2021-04-12T11:41:13","date_gmt":"2021-04-12T10:41:13","guid":{"rendered":"https:\/\/www.heartfailurematters.org\/vad-kan-din-lakare-gora\/sgc-stimulerare\/"},"modified":"2021-06-25T17:24:41","modified_gmt":"2021-06-25T16:24:41","slug":"sgc-stimulerare","status":"publish","type":"page","link":"https:\/\/www.heartfailurematters.org\/sv\/vad-din-lakare-eller-sjukskoterska-kan-gora\/sgc-stimulerare\/","title":{"rendered":"SGC-stimulerare"},"content":{"rendered":"

L\u00f6sligt guanylatcyklas (sGS) och aktivatorer minskar oxidativ stress genom att \u00f6ka niv\u00e5erna av kv\u00e4veoxid i hj\u00e4rta och blodk\u00e4rl. Dessa l\u00e4kemedel \u00e4r nya och kan bara anv\u00e4ndas f\u00f6r hj\u00e4rtsviktsbehandling i begr\u00e4nsad omfattning. Ett s\u00e5dant sGCS-medel \u00e4r riociguat som \u00e4r godk\u00e4nt f\u00f6r behandling av ett specifikt tillst\u00e5nd som kallas pulmonell hypertension, vilket p\u00e5verkar blodk\u00e4rlen i lungorna. Ett annat sGCS-medel \u00e4r vericiguat som, n\u00e4r det anv\u00e4nds i kombination med standardl\u00e4kemedel, kan bidra till att f\u00f6rhindra nya sjukhusvistelser hos patienter med sv\u00e5r hj\u00e4rtsvikt.<\/p>\n

Verkan:<\/strong> Ungef\u00e4r en fj\u00e4rdedel av hj\u00e4rtsviktspatienterna har l\u00e5ga niv\u00e5er av cykliskt guanosinmonofosfat (cGMP). CGMP-molekylen \u00e4r en viktig intracellul\u00e4r budb\u00e4rare, som skyddar hj\u00e4rta, k\u00e4rl och njurar. En av CGMP-molekylens viktigaste effekter \u00e4r avslappning i blodk\u00e4rl och hj\u00e4rtceller. L\u00f6sliga guanylatcyklasstimulatorer (sGCS) \u00f6kar bildningen av cGMP och minskar d\u00e4rf\u00f6r stelheten i hj\u00e4rtceller och -k\u00e4rl.<\/p>\n

Vilka f\u00f6rdelar kan man f\u00f6rv\u00e4nta sig?<\/strong> Hos patienter som lagts in p\u00e5 sjukhus f\u00f6r hj\u00e4rtsvikt och som har en ejektionsfraktion fr\u00e5n v\u00e4nster kammare som \u00e4r l\u00e4gre \u00e4n 45 %, kan vericiguat minska antalet hj\u00e4rtsviktsrelaterade \u00e5terinl\u00e4ggningar p\u00e5 sjukhus och f\u00f6rl\u00e4nga livet.<\/p>\n

Biverkningar: <\/strong>Vericiguat tolereras v\u00e4l j\u00e4mf\u00f6rt med placebo. Symtomatisk hypotension (f\u00f6r l\u00e5gt blodtryck) och anemi rapporterades hos ett litet antal patienter.<\/p>\n

Tips:<\/strong> Vericiguat ska tas oralt i tablettform en g\u00e5ng dagligen. Som med andra hj\u00e4rtsviktsl\u00e4kemedel ska dosen l\u00e5ngsamt h\u00f6jas i flera steg.<\/p>\n

 <\/p>\n

\u00c5terg\u00e5 till ”L\u00e4kemedel vid hj\u00e4rtsvikt”<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

L\u00f6sligt guanylatcyklas (sGS) och aktivatorer minskar oxidativ stress genom att \u00f6ka niv\u00e5erna av kv\u00e4veoxid i hj\u00e4rta och blodk\u00e4rl. Dessa l\u00e4kemedel \u00e4r nya och kan bara anv\u00e4ndas f\u00f6r hj\u00e4rtsviktsbehandling i begr\u00e4nsad omfattning. Ett s\u00e5dant sGCS-medel \u00e4r riociguat som \u00e4r godk\u00e4nt f\u00f6r behandling av ett specifikt tillst\u00e5nd som kallas pulmonell hypertension, vilket p\u00e5verkar blodk\u00e4rlen i lungorna. Ett […]<\/p>\n","protected":false},"author":1,"featured_media":10874,"parent":2685,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-8136","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nSGC-stimulerare - Heart Failure Matters<\/title>\n<meta name=\"description\" content=\"L\u00f6sligt guanylatcyklas (sGS) och aktivatorer minskar oxidativ stress orsakad av \u00f6kade niv\u00e5er av kv\u00e4veoxid i hj\u00e4rta och blodk\u00e4rl.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.heartfailurematters.org\/sv\/vad-din-lakare-eller-sjukskoterska-kan-gora\/sgc-stimulerare\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SGC-stimulerare - 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